TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer

N Kaushik, A Jaiswal, P Bhartiya, EH Choi… - Cancer and Metastasis …, 2024 - Springer
… unusual DNA-binding activity, these transcription factors are … T lymphocytes, inducers of
cell growth can increase CP2's … The mitogenic stimulus binds TFCP2 to the essential promoter …

[HTML][HTML] Forging a functional cure for HIV: transcription regulators and inhibitors

S Mediouni, S Lyu, SM Schader, ST Valente - Viruses, 2022 - mdpi.com
… or either host transcriptional factors and chromatin regulators, … confirmed in primary cells
and resting CD4 + T cells from an … -κB in the nucleus increases its DNA-binding affinity. Several …

[HTML][HTML] HIV Expression in Infected T Cell Clones

JW Rausch, S Parvez, S Pathak, AA Capoferri… - Viruses, 2024 - mdpi.com
… upon host cell and viral transcription factors binding to an array … II transcription complexes,
CDK9-mediated phosphorylation … by DNA sequence, DNA binding proteins, and the activity of …

[PDF][PDF] critical role of the transcription factor Miz-1 in T cell activation and maturation

AS Mägdefrau - 2023 - db-thueringen.de
… These cells show a fast and efficient response to the … the linker for activation of T cells (LAT)
through phosphorylation, … of which are important for its DNA binding capacity. An important …

Structural Basis of Gene Regulation by the Transcription Factors Tfcp2l1 and Tfcp2

J Wang - 2022 - refubium.fu-berlin.de
… 40 transcription factor (LSF) was first described in HeLa cells … regulated by mitogenic signaling
pathways during cell growth… of Tfcp2 DNA binding activity upon activation of resting T cells

[HTML][HTML] Grainyhead-like 2 as a double-edged sword in development and cancer

…, C Feng, H Zhu, S Wu, P Jin, T Xu - American journal of …, 2020 - ncbi.nlm.nih.gov
… , the LSF subfamily including CP2, LBP-1a, and LBP-9 … GRHL transcription factors are
classified as DNA-binding … leading to activation of Smad2 and Smad3 by phosphorylation, p-…

Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension

A Chen, G Gao, G Lian, J Gong, L Luo, J Liu, W Chen… - Cell Cycle, 2023 - Taylor & Francis
… A one-way analysis of variance (ANOVA), followed by an LSD (… the transcriptional activity of
MTF-1, and phosphorylation … , DNA binding, and MTF-1 transcriptional activation, have been …

Steering molecular activity with optogenetics: recent advances and perspectives

TJ Oh, H Fan, SS Skeeters, K Zhang - Advanced biology, 2021 - Wiley Online Library
… domains to the promoter, controlling the transcription factor's … A common strategy to probe
the kinetic proofreading in T cells is … DNA-binding protein 43 kDa (optoTDP43) with CRY2olig …

[HTML][HTML] … dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

L Fornari Laurindo, J Aparecido Dias… - Frontiers in …, 2024 - frontiersin.org
… of NF-κB signaling, T cells also undergo differentiation and activation driven by …
transcription with non-STAT transcription factors by binding to clusters of independent DNA-binding

[HTML][HTML] A specific peptide with immunomodulatory activity from Pseudostellaria heterophylla and the action mechanism

Q Yang, X Cai, M Huang, S Wang - Journal of Functional Foods, 2020 - Elsevier
T lymphocytes (T cells) and B lymphocytes (B cells) play … NF-κB is an important transcriptional
factor which can be … as a mitogen for murine spleen lymphocytes and could cause T